KINASE INHIBITOR SCREENING IDENTIFIES CYCLIN-DEPENDENT KINASES AND GLYCOGEN SYNTHASE KINASE 3 AS POTENTIAL MODULATORS OF TDP-43 CYTOSOLIC ACCUMULATION DURING CELL STRESS.

Abnormal processing of TAR DNA binding protein 43 (TDP-43) has Conference Room Tables been identified as a major factor in neuronal degeneration during amyotrophic lateral sclerosis (ALS) or frontotemporal lobar degeneration (FTLD).It is unclear how changes to TDP-43, including nuclear to cytosolic translocation and subsequent accumulation, are con

In this study, we explored the developmental characteristics of Pinellia ternate bulbils as well as the key gene networks driving the development of bulbils.Based on physiological and biochemical reactions as well as transcriptome technology, this study determined the content of endogenous metabolites and related enzyme activities during the five g

Future driver information systems will consist of a plurality of information components containing the classic instrumentation like instrument cluster, radio and trip computers, but also new components like car telephones, navigation systems and even TV.This development leads firstly to a new kind of instrument cluster design and secondly to a rath

Regina Fölster-Holst,1 Jagoda Galecka,1 Sigo Weißmantel,1 Ute Dickschat,2 Frank Rippke,3 Kerstin Bohnsack,3 Thomas Werfel,4 Katja Wichmann,4 Matthias Buchner,1 Thomas Schwarz,1 Annika Vogt,5 Jürgen Lademann,5 Martina C Meinke5 1Department of Dermatology, Venerology and Allergy, University of Kiel, 2Wörth, 3Beiersdorf AG, Hambur